PI3Kα-IN-22

PI3Kα-IN-22 (Compound 17) is an orally active, potent and selective inhibitor of PI3Kα H1047R, with an IC50 of 1 nM for pAKT T47D AlphaLISA. PI3Kα-IN-22 can induce tumor regressions in the HCC1954 tumor model in mice .


Cat. No.: EX-A9598	Purity: >98%

	Chemical structure of PI3Kα-IN-22

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
500mg	1250	In-stock
1g	2450	In-stock

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Synonyms	PI3Kalpha-IN-22
CAS No.	2925030-26-6
Purity	>98%
Formula	C24H23F2N5O3
Mol Weight	467.4679
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ketcham JM, et al. Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein. J Med Chem. 2024 Mar 28;67(6):4936-4949.
CoA	CoA of PI3Kα-IN-22

Smiles:	[C@@H](NC1=C(C(O)=O)C=CC=C1)(C)C=2C=3N(C(=O)C(C#N)=C(N3)N4CCC(F)(F)CC4)C=C(C)C2


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