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Product Information:

PI3Kα-IN-1

PI3Kα-IN-1 is a PI3Kα inhibitor (IC50 < 0.5 nM), and also inhibits mTOR (IC50: 104 nM) .

Cat. No.: EX-A16704    Purity: >98%
Chemical
Chemical structure of PI3Kα-IN-1


For research only, Do not use for Human!

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CAS No.2100855-80-7
Purity>98%
FormulaC26H25N7O3
Mol Weight483.5218
 
 
Reference:  

[1]. Al-Ashmawy AAK, et al. Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3117-3122.

CoACoA of PI3Kα-IN-1
Smiles:CC(NC1=CC=C(NC(NC2=CC=C(C3=NC(N4CCOCC4)=C5C(C=CC=N5)=N3)C=C2)=O)C=C1)=O

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