PHPS1

PHPS1 is a potent and selective Shp2 inhibitor with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively .


Cat. No.: EX-A7998	Purity: >98%

	Chemical structure of PHPS1

For research only, Do not use for Human!

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CAS No.	314291-83-3
Purity	>98%
Formula	C21H15N5O6S
Mol Weight	465.439
Color	Red to reddish brown
State	solid powder
Solubility	DMSO : 25 mg/mL
Shelf Life	>1 years if stored properly
Storage	-20°C, sealed storage, away from moisture
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Klaus Hellmuth, et al. Specific Inhibitors of the Protein Tyrosine Phosphatase Shp2 Identified by High-Throughput Docking. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7275-80. [2].Jia Chen, et al. SHP2 Inhibitor PHPS1 Protects Against Atherosclerosis by Inhibiting Smooth Muscle Cell Proliferation. BMC Cardiovasc Disord. 2018 Apr 27;18(1):72.
CoA	CoA of PHPS1

Smiles:	O=S(C1=CC=C(N/N=C2C(C3=CC=C([N+]([O-])=O)C=C3)=NN(C4=CC=CC=C4)C\2=O)C=C1)(O)=O


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