Phosphodiesterase-IN-2

Phosphodiesterase-IN-2 (Compound C7) is a selective, orally active inhibitor for phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. Phosphodiesterase-IN-2 improves the stability of liver microsomes, and lowers BBB permeability. Phosphodiesterase-IN-2 exhibits good pharmacokinetic characters, and attenuates isoprenaline -induced cardiac hypertrophic in mouse models .


Cat. No.: EX-A15537	Purity: >98%

	Chemical structure of Phosphodiesterase-IN-2

For research only, Do not use for Human!

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CAS No.	3047610-96-5
Purity	>98%
Formula	C32H27F3N6O2
Mol Weight	584.591
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yuan H, et al., Discovery of 3-trifluoromethyl-substituted pyrazoles as selective phosphodiesterase 10A inhibitors for orally attenuating isoprenaline-induced cardiac hypertrophy[J]. Chinese Chemical Letters, 2024: 109965.
CoA	CoA of Phosphodiesterase-IN-2

Smiles:	FC(F)(F)C(C=C1C2=CC(C)=NC=C2)=NN1C3=CC=C(OCC4=NC5=C(C=CC=C5)C(C(N6CC7(CNC7)C6)=O)=C4)C=C3


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