PhIP

PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity.


Cat. No.: EX-A11049	Purity: >98%

	Chemical structure of PhIP

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	585	In-stock
250mg	1115	In-stock
500mg	1785	In-stock
1g	2685	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	105650-23-5
Purity	>98%
Formula	C13H12N4
Mol Weight	224.2612
Color	White to light yellow
State	Solid
Solubility	DMSO : 25 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bellamri M, et al. Metabolic Activation of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Human Prostate. Toxicol Sci. 2018 Jun 1;163(2):543-556. [2]. Papaioannou MD, et ak. The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells. Toxicol Lett. 2014 Aug 17;229(1):9-16. [3]. Ochiai M, et al. DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis. Carcinogenesis. 1996 Jan;17(1):95-8. [4]. Nakagama H, et al. A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP. Mutat Res. 2002 Sep 30;506-507:137-44. [5]. Tsuneyuki U, et al. Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine in combination with a high fat diet , Carcinogenesis, Volume 23, Issue 1, January 2002, Pages 197-200. [6]. Wang H, et al. Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation of Apc. Carcinogenesis. 2016 Jul;37(7):723-730.
CoA	CoA of PhIP

Smiles:	NC1=NC2=NC=C(C=C2N1C)C3=CC=CC=C3


		Search