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Product Information:

PGD97

PGD97 is a selective cyclic peptide inhibitor against CAL/CFTR interactions, with a KD value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis .

Cat. No.: EX-A8882    Purity: >98%
Chemical
Chemical structure of PGD97


For research only, Do not use for Human!

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SynonymsCAL/CFTR Inhibitor
Synonyms 2CAL-CFTR Inhibitor
CAS No.2717490-36-1
Purity>98%
FormulaC74H111N23O14S3
Mol Weight1643.014
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Dougherty PG, et al. Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis. J Med Chem. 2020, 63(24):15773-15784.

CoACoA of PGD97

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