PFI-6

PFI-6 is a non-cytotoxic and selective MLLT1/3 probe targeting the YEATS domain of MLLT1 (ENL/YEATS1) (IC50 values of 140 nM) and MLLT3 (AF9/YEATS3) (IC50 values of 160 nM).


Cat. No.: EX-A5086	Purity: >98%

	Chemical structure of PFI-6

For research only, Do not use for Human!

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CAS No.	2675452-91-0
Purity	>98%
Formula	C22H21N3O4
Mol Weight	391.4198
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 25 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Raux B, et al. Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg Med Chem Lett. 2023 Nov 7:129546.
CoA	CoA of PFI-6

Smiles:	N(C(=O)C=1C=C(ON1)C2=CC(O)=C(C(N(C)C)=O)C=C2)[C@H]3C=4C(CC3)=CC=CC4


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