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Product Information:

PF 543 HCl

PF-543 hydrochloride is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM.

Cat. No.: EX-A7103A    Purity: >98%
Chemical
Chemical structure of PF 543 HCl


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
500mg900In-stock
1g1450In-stock
5g4350In-stock


SynonymsPF-543 HCl
Synonyms 2Sphingosine Kinase 1 Inhibitor II hydrochloride
CAS No.1706522-79-3
Purity>98%
FormulaC27H32ClNO4S
Mol Weight502.065
Statesolid powder
Shelf Life>3 years if stored properly
StoragePowder 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Schnute ME, et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88.

[2]. MacRitchie N, et al. Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cell Signal. 2016 Aug;28(8):946-55.

[3]. Hamada M, et al. Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells. Cell Death Discov. 2017 Aug 14;3:17047.

CoACoA of PF 543 HCl

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