PF-3644022

PF-3644022 is a potent MK2 inhibitor with IC50 = 5.2 nM; Ki = 3 nM. PF-3644022 inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM).


Cat. No.: EX-A5241	Purity: >98%

	Chemical structure of PF-3644022

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	585	In-stock
100mg	800	In-stock
200mg	1250	In-stock
500mg	1850	In-stock
1g	3000	In-stock
5g	9350	In-stock

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CAS No.	1276121-88-0
Purity	>98%
Formula	C21H18N4OS
Mol Weight	374.459
Color	Light yellow to yellow
State	solid powder
Solubility	Soluble in DMSO 41.67 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Song H, et al. Role of MK2 signaling pathway in the chronic compression of cervical spinal cord. Am J Transl Res. 2015 Nov 15;7(11):2355-63. eCollection 2015. PubMed PMID: 26807183; PubMed Central PMCID: PMC4697715. [2]. Mourey RJ, et al. A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J Pharmacol Exp Ther. 2010 Jun;333(3):797-807. doi: 10.1124/jpet.110.166173. Epub 2010 Mar 17. PubMed PMID: 20237073.
CoA	CoA of PF-3644022

Smiles:	O=C1C2=C(NC[C@@H](C)N1)C3=C(C=CC4=NC(C5=CN=C(C)C=C5)=CC=C34)S2


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