PF-06826647

Ropsacitinib (PF-06826647) is a selective and orally administered inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 17 nM for binding to TYK2 catalytically active JH1 domain. PF-06826647 (Tyk2-IN-8) also inhibits JAK1 and JAK2 with IC50 of 383 nM and 74 nM, respectively. PF-06826647 (Tyk2-IN-8) is used in the treatment of psoriasis (PSO).


Cat. No.: EX-A4020	Purity: >98%

	Chemical structure of PF-06826647

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	550	In-stock
25mg	850	In-stock
50mg	1350	In-stock
100mg	2200	In-stock
250mg	3200	In-stock
500mg	4800	In-stock

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Synonyms	Ropsacitinib
Synonyms 2	Tyk2-IN-8
CAS No.	2127109-84-4
Purity	>98%
Formula	C20H17N9
Mol Weight	383.4093
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wrobleski, Stephen T et al. “Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.” Journal of medicinal chemistry vol. 62,20 (2019): 8973-8995. [2]. Gerstenberger, Brian S et al. “Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.” Journal of medicinal chemistry vol. 63,22 (2020): 13561-13577.
CoA	CoA of PF-06826647

Smiles:	N#CC[C@@]1(N2N=CC(C3=NC(C4=CN(C)N=C4)=CN5C3=CC=N5)=C2)C[C@@H](C#N)C1


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