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Product Information:

PF-06821497

PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition.

Cat. No.: EX-A2697    Purity: >98%
Chemical
Chemical structure of PF-06821497


For research only, Do not use for Human!

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CAS No.1844849-11-1
Purity>98%
FormulaC22H24Cl2N2O5
Mol Weight467.342
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Kung PP, Bingham P, Brooun A, et al. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J Med Chem. 2018;61(3):650-665. doi:10.1021/acs.jmedchem.7b01375

[2]. Development of a Cost-Efficient Process Toward a Key Synthetic Intermediate of the EZH2 Inhibitor PF-06821497 Christopher P. Ashcroft, Alexander M. Berne, Florian Blasberg, Kelly Catlin, Michael R. Collins, Doug J. Critcher, Jean-Nicolas Desrosiers, Adam Goetz, Cheryl Hayward, Ricky A. Jones, Michael J. Karmilowicz, Nandell Keene, Carlos A. Martinez, Sebastien Monfette, Sebastian David Pattavina, Hahdi H. Perfect, John A. Ragan, Blake Rauschenberger, Neal W. Sach, Gemma Scotney, Scott C. Sutton, Courtney Talicska, Steven J.R. Twiddle, Jared Van Haitsma, and Richard Wisdom Organic Process Research & Development Article ASAP DOI: 10.1021/acs.oprd.3c00477

CoACoA of PF-06821497
Smiles:CO[C@@H](C1COC1)C1=C(Cl)C2=C(CCN(CC3=C(OC)C=C(C)NC3=O)C2=O)C(Cl)=C1

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