PF-06446846 hydrochloride

PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34.


Cat. No.: EX-A7051A	Purity: >98%

	Chemical structure of PF-06446846 hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	650	In-stock
500mg	950	In-stock
1g	1800	In-stock
2g	3300	In-stock
5g	6500	In-stock

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CAS No.	1632250-50-0
Purity	>98%
Formula	C22H21Cl2N7O
Mol Weight	470.354
Color	light yellow to khaki
State	solid
Solubility	Soluble in DMSO, water
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Lintner NG, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar 21;15(3):e2001882.
CoA	CoA of PF-06446846 hydrochloride

Smiles:	O=C(O)CN1CCN(CC(=O)O)CCN(CC1)CC(N(CC(=O)O)CC(=O)O)CCCC2=CC=C(N=C=S)C=C2


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