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Product Information:

PF-04447943

Edelinontrine (PF-04447943) is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM).

Cat. No.: EX-A7959    Purity: 98+%
Chemical
Chemical structure of PF-04447943


For research only, Do not use for Human!

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SynonymsEdelinontrine
CAS No.1082744-20-4
Purity98+%
FormulaC20H25N7O2
Mol Weight395.4582
ColorLight yellow to yellow
Statesolid powder
SolubilityDMSO : ? 54.6 mg/mL
Shelf Life>3 years if stored properly
StoragePowder   -20°C, 3 years , 4°C, 2 years ; In solvent    -20°C, 1 year
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Kleiman RJ, et al. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. J Pharmacol Exp Ther. 2012 May;341(2):396-409.

[2]. Hutson, P. H, et al. The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and

CoACoA of PF-04447943

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