PF-03654764

PF-03654764 is an orally active, selective histamine H3 receptor antagonist with Ki values of 1.2 nM and 7.9 nM for human H3 and rat H3 in whole cell assay, respectively. The combination of PF-03654764 and Fexofenadine has the potential for allergic rhinitis research .


Cat. No.: EX-A10452	Purity: >98%

	Chemical structure of PF-03654764

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
50mg	1172	In-stock
100mg	1856	In-stock

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CAS No.	935840-35-0
Purity	>98%
Formula	C20H28F2N2O
Mol Weight	350.4459
Color	white to off-white
State	powder
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 year; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Travis T Wager, et al. Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764). J Med Chem. 2011 Nov 10;54(21):7602-20. [2]. Michelle L North, et al. Add-on histamine receptor-3 antagonist for allergic rhinitis: a double blind randomized crossover trial using the environmental exposure unit. Allergy Asthma Clin Immunol. 2014 Jul 3;10(1):33.
CoA	CoA of PF-03654764

Smiles:	O=C([C@@H]1C[C@@](C2=CC(F)=C(CN3CCCC3)C=C2)(F)C1)NCC(C)C


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