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Product Information:

PF-00446687

PF-00446687 is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 ± 1 nM . Pf-446687 is brain penetrant .

Cat. No.: EX-A10689    Purity: >98%
Chemical
Chemical structure of PF-00446687


For research only, Do not use for Human!

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SynonymsPF-00446687 free base
CAS No.862281-92-3
Purity>98%
FormulaC28H36F2N2O2
Mol Weight470.5944
ColorWhite to off-white
StateSolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 year;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Lansdell MI, et al. Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans. J Med Chem. 2010 Apr 22;53(8):3183-97.

[2]. Modi ME, et al. Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40(8):1856-65.

CoACoA of PF-00446687
Smiles:O=C(N(C[C@@H]1C)C[C@H]([C@@]1(O)C2=CC=CC=C2)C)[C@H](C3)[C@H](C(C=CC(F)=C4)=C4F)CN3C(C)(C)C

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