Peptide IS4

IS4 is a selective CXCR4 competitive antagonist, with an IC50 of 0.65 nM in THP-1 cells and 38.75 nM in Jurkat cells. IS4 is stable in serum and non-cytotoxic. IS4 competitively binds to CXCR4 with CXCL12, thereby inhibiting CXCL12-induced intracellular Ca 2+ release and cancer cell migration. IS4 can be used in the research on the prevention of metastasis of breast cancer, prostate cancer, leukemia, and other diseases .


Cat. No.: EX-A16094	Purity: >98%

	Chemical structure of Peptide IS4

For research only, Do not use for Human!

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Synonyms 2	CXCL12-derived cyclic peptide IS4
CAS No.	3067986-23-3
Purity	>98%
Formula	C48H62N14O11S2
Mol Weight	1075.223
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hamshaw I, et al. The development of potent, competitive CXCR4 antagonists for the prevention of cancer metastasis. Biochem Pharmacol. 2023 Dec;218:115921.
CoA	CoA of Peptide IS4

Smiles:	O=C1C2=C(C(=O)N1CC#C)SC[C@@H](C(O)=O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)C)=O)CS2


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