PDM-631

PDM-631 is a selective and orally active PDE2A inhibitor with blood-brain barrier penetration. PDM-631 exhibits potent inhibitory activity against human and rat recombinant PDE2A with IC50 values of 1.5 nM and 4.2 nM, respectively. PDM-631 increases cGMP levels in the rat cerebral cortex. PDM-631 can be used for the study of schizophrenia and neurodegenerative disorders .


Cat. No.: EX-A15955	Purity: >98%

	Chemical structure of PDM-631

For research only, Do not use for Human!

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CAS No.	2095312-08-4
Purity	>98%
Formula	C19H19F3N4O2
Mol Weight	392.375
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Maehara S, et al. Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 2A inhibitor, PDM-631. Eur J Pharmacol. 2017 Sep 15;811:110-116.
CoA	CoA of PDM-631

Smiles:	[C@@H](CC1=CC=C(OC(F)(F)F)C=C1)(C)N2C3=C(C(=N2)C4CC4)C(=O)N=C(C)N3


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