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Product Information:

PDK-IN-1

PDK-IN-1 (compound 7o) is a pyruvate dehydrogenase kinase (PDK) inhibitor. PDK-IN-1 shows IC50 values of 0.03 and 0.1 μM for PDK1 and HSP90, respectively. PDK-IN-1 targets PDH/PDK axis thus reducing efficiently the tumor mass.

Cat. No.: EX-A11477    Purity: >98%
Chemical
Chemical structure of PDK-IN-1


For research only, Do not use for Human!

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CAS No.2897696-10-3
Purity>98%
FormulaC20H16BrN7O
Mol Weight450.291
Coloroff-white to yellow
StateSolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4℃, sealed storage, away from moisture and light, 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Pecoraro C, et al. 1,2,4-Amino-triazine derivatives as pyruvate dehydrogenase kinase inhibitors: Synthesis and pharmacological evaluation. Eur J Med Chem. 2023 Mar 5;249:115134.

CoACoA of PDK-IN-1
Smiles:BrC=1C=NC2=C(C1)C(=CN2C)C=3N=C(N=NC3C4=CNC=5C=CC(OC)=CC54)N

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