PDEδNAMPT IN-1

PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) (KD=0.410 nM) and nicotinamide phosphoribosyl transferase (NAMPT) (IC50=2.21 nM). PDEδ/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide (NAD+), inducing apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer.


Cat. No.: EX-A14028	Purity: >98%

	Chemical structure of PDEδNAMPT IN-1

For research only, Do not use for Human!

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CAS No.	2976498-55-0
Purity	>98%
Formula	C26H30N4O4S
Mol Weight	494.606
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhu Y, et al. Discovery of Potent PDEδ/NAMPT Dual Inhibitors: Preclinical Evaluation in KRAS Mutant Pancreatic Cancer Cells. J Med Chem. 2025 May 8;68(9):9241-9259.
CoA	CoA of PDEδNAMPT IN-1

Smiles:	O=S(C1=CC=C(C=C1)NC(NCC2=CC=CN=C2)=O)(N(CC3=CC=C(C=C3)OC)C4CCCC4)=O


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