PDEδ autophagic degrader 1

PDEδ autophagic degrader 1 (compound 12c) is a potent PDEδ autophagic degrader. PDEδ autophagic degrader 1 reduces the PDEδ protein level through lysosome-mediated autophagy without affecting the PDEδ mRNA expression. PDEδ autophagic degrader 1 suppresses the growth in KRAS mutant pancreatic cancer cells.


Cat. No.: EX-A8424	Purity: >98%

	Chemical structure of PDEδ autophagic degrader 1

For research only, Do not use for Human!

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Purity	>98%
Formula	C41H42Br2IN7O5
Mol Weight	999.529
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jingying Bao, et al. Discovery of Novel PDEδ Autophagic Degraders: A Case Study of Autophagy-Tethering Compound (ATTEC). ACS Med Chem Lett. 2023 Dec 29;15(1):29-35.
CoA	CoA of PDEδ autophagic degrader 1

Smiles:	CC1=CC=C(N2C(C)=C(C(C)=NN(CCCC(NCCCCCCNC(COC3=C(Br)C=C(/C=C4C(C=C(I)C=C5)=C5NC/4=O)C=C3Br)=O)=O)C6=O)C6=N2)C=C1


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