PDE4-IN-34

PDE4-IN-34 is a phosphodiesterase 4 (PDE4) inhibitor, with IC50 values of 19 pM and 14 pM against PDE4B1 and PDE4D2, respectively. PDE4-IN-34 shows weak inhibitory activity against PDE8A1, with an IC50 value of 4.092 μM, and exhibits significant selectivity over other subtypes (IC50 > 10 μM). PDE4-IN-34 improves pulmonary function, reduces inflammatory responses and alleviates lung tissue damage in a rat model induced by cigarette smoke combined with LPS (HY-D1056). PDE4-IN-34 can be used for research related to chronic obstructive pulmonary disease .


Cat. No.: EX-A16664	Purity: >98%

	Chemical structure of PDE4-IN-34

For research only, Do not use for Human!

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CAS No.	3052591-16-6
Purity	>98%
Formula	C17H11Cl3N2O2
Mol Weight	381.64

Reference:	[1].Xing G, et al. Discovery, Synthesis, and Biological Evaluation of Novel Quinoline-Based PDE4 Inhibitors with Potent Anti-Chronic Obstructive Pulmonary Disease Activity. J Med Chem. 2026;69(4):3852-3867.
CoA	CoA of PDE4-IN-34

Smiles:	O=C(C=1C=CC(OC)=C2N=C(Cl)C=CC21)CC=3C(Cl)=CN=CC3Cl


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