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Product Information:

PDE4-IN-22

PDE4-IN-22 (Compound 2e) is a PDE4 inhibitor with an IC50 value of 2.4 nM. PDE4-IN-22 exhibits anti-inflammatory activity and demonstrates significant anti-psoriatic effects in an Imiquimod-induced psoriasis mouse model.

Cat. No.: EX-A15557    Purity: >98%
Chemical
Chemical structure of PDE4-IN-22


For research only, Do not use for Human!

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CAS No.3087059-00-2
Purity>98%
FormulaC22H19F4N3O3
Mol Weight449.3982
 
 
Reference:  

[1]. Li G, et al. Development of selective heterocyclic PDE4 inhibitors for treatment of psoriasis[J]. European Journal of Medicinal Chemistry, 2024, 280: 116930.

CoACoA of PDE4-IN-22
Smiles:O=C(C1=CNC(C2=CC=C(OC(F)F)C(OCC3CC3)=C2)=N1)NCC4=CC(F)=CC=C4F

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