PDE1-IN-4

PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research.


Cat. No.: EX-A12449	Purity: >98%

	Chemical structure of PDE1-IN-4

For research only, Do not use for Human!

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CAS No.	3031349-98-8
Purity	>98%
Formula	C33H33N3O4
Mol Weight	535.6328
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Huang MX, et al. Structural Modifications of Nimodipine Lead to Novel PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects. J Med Chem. 2022 Jun 23;65(12):8444-8455.
CoA	CoA of PDE1-IN-4

Smiles:	C(O[C@H](C)C1=CC=CC=C1)(=O)C=2C(C(C(O[C@H](C)C3=CC=CC=C3)=O)=C(C)NC2C)C=4C=C5C(=CC4)N(C)N=C5


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