PD 144418

PD 144418 is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 shows potential antipsychotic activity .


Cat. No.: EX-A6830A	Purity: >98%

	Chemical structure of PD 144418

For research only, Do not use for Human!

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CAS No.	154130-99-1
Purity	>98%
Formula	C18H22N2O
Mol Weight	282.3801
Color	Light yellow to brown
State	Viscous Liquid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Akunne HC, et al. The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology. 1997 Jan;36(1):51-62. [2]. Lever JR, et al. Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J Pharmacol Exp Ther. 2014 Oct;351(1):153-63.
CoA	CoA of PD 144418

Smiles:	CCCN1CC(C2=CC(C3=CC=C(C)C=C3)=NO2)=CCC1


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