PD-1/PD-L1-IN-13

PD-1/PD-L1-IN-13 (Compound 43) is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM. PD-1/PD-L1-IN-13 promots CD8+ T cell activation and delays the tumor growth in the Hepa1-6 syngeneic mouse model.


Cat. No.: EX-A17049	Purity: >98%

	Chemical structure of PD-1/PD-L1-IN-13

For research only, Do not use for Human!

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CAS No.	2865841-81-0
Purity	>98%
Formula	C36H34ClF2N3O9
Mol Weight	726.12
Color	White to off-white
State	Solid
Solubility	DMSO : 150 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C 3 years, 4°C 2 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Song Z, et al. Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage. J Med Chem. 2021;64(22):16687-16702.
CoA	CoA of PD-1/PD-L1-IN-13

Smiles:	CC1=C(C=CC=C1C(F)(F)OC2=C(Cl)C=C(CN[C@@H]3C(O)O[C@H](CO)[C@@H](O)[C@@H]3O)C(OCC4=CC(C#N)=NC=C4)=C2)C5=CC=C(OCCO6)C6=C5


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