PBTZ169

Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2'-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect.


Cat. No.: EX-A1013	Purity: >98%

	Chemical structure of PBTZ169

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	400	In-stock
500mg	640	In-stock
1g	1020	In-stock
2g	1620	In-stock
3g	1950	In-stock
5g	2600	In-stock

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Synonyms	Macozinone
CAS No.	1377239-83-2
Purity	>98%
Formula	C20H23F3N4O3S
Mol Weight	456.482
Color	light yellow to yellow
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. [3] Makarov V et al. Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol Med. 2014 Mar;6(3):372-83.
CoA	CoA of PBTZ169

Smiles:	[O-][N+](=O)C1=C2SC(=NC(=O)C2=CC(=C1)C(F)(F)F)N1CCN(CC2CCCCC2)CC1


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