PBT-434

PBT434 (ATH434) free base is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 free base can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 free base inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 free base prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 free base has the potential for the research of Parkinson’s disease (PD).


Cat. No.: EX-A13450	Purity: >98%

	Chemical structure of PBT-434

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
100mg	get quote
1g	get quote

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


Synonyms	PBT434
CAS No.	1232840-87-7
Purity	>98%
Formula	C12H13Cl2N3O2
Mol Weight	302.157
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Finkelstein DI, et al. The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease. Acta Neuropathol Commun. 2017 Jun 28;5(1):53. [2]. Bailey DK, et al. The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells. PLoS One. 2021 Jul 26;16(7):e0254794.
CoA	CoA of PBT-434

Smiles:	O=C1C=2C(Cl)=CC(Cl)=C(O)C2N=C(N1C)CNCC


		Search