PBIT

PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC50s of 6 μM and 4.9 μM, respectively[1].


Cat. No.: EX-A14676	Purity: >98%

	Chemical structure of PBIT

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	395	In-stock
250mg	495	In-stock
500mg	695	In-stock
1g	925	In-stock

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CAS No.	2514-30-9
Purity	>98%
Formula	C14H11NOS
Mol Weight	241.308
Color	Off-white to brown
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17.
CoA	CoA of PBIT

Smiles:	CC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3S2


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