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Product Information:

PARPNAMPT-IN-1

PARP1/NAMPT-IN-2 (Compound 13j) is a dual PARP/NAMPT inhibitor with IC50 values of 0.8 nM and 18 nM for PARP1 and NAMPT, respectively. PARP1/NAMPT-IN-2 can inhibit the proliferation, migration and induce apoptosis of breast cancer cells. PARP1/NAMPT-IN-2 can be used for the research of triple-negative breast cancer.

Cat. No.: EX-A14027    Purity: >98%
Chemical
Chemical structure of PARPNAMPT-IN-1


For research only, Do not use for Human!

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CAS No.2755825-45-5
Purity>98%
FormulaC34H36FN7O3
Mol Weight609.6931
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Mao J, et al. Discovery of dual PARP/NAMPT inhibitors for the treatment of BRCA wild-type triple-negative breast cancer. Bioorg Med Chem Lett. 2025 Jan 30;120:130117.

CoACoA of PARPNAMPT-IN-1
Smiles:O=C(NCCCCCCN1CCN(C(C2=C(F)C=CC(CC3=NNC(C4=C3C=CC=C4)=O)=C2)=O)CC1)C5=CC6=NC=CN6C=C5

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