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Product Information:

PARP7-IN-16

PARP7-IN-16 (compound 36) is a potent, selective and orally active inhibitor of PARP-1/2/7, with IC50s of 0.94, 0.87 and 0.21 nM, respectively. PARP7-IN-16 can be used for the research of breast cancer and prostate cancer.

Cat. No.: EX-A12026A    Purity: >98%
Chemical
Chemical structure of PARP7-IN-16


For research only, Do not use for Human!

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CAS No.2435657-10-4
Purity>98%
FormulaC25H26FN4NaO4
Mol Weight488.4865
ColorWhite to off-white
StateSolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder 4℃, sealed storage, away from moisture, 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Zhou J, et, al. Discovery of Quinazoline-2,4(1 H,3 H)-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J Med Chem. 2023 Oct 26;66(20):14095-14115.

CoACoA of PARP7-IN-16
Smiles:CCC(CC)N1CCN(CC1=O)C(=O)C2=C(C=CC(=C2)CN3C4=CC=CC=C4C(=O)[N-]C3=O)F.[Na+]

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