P62-mediated mitophagy inducer

P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential.


Cat. No.: EX-A11317	Purity: >98%

	Chemical structure of P62-mediated mitophagy inducer

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
1g	550	In-stock
5g	1950	In-stock

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CAS No.	1809031-84-2
Purity	>98%
Formula	C14H9IN4O2
Mol Weight	392.1513
Color	Light yellow to yellow
State	solid
Solubility	DMSO : 8.33 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. East DA, et al. PMI: a ΔΨm independent pharmacological regulator of mitophagy. Chem Biol. 2014 Nov 20;21(11):1585-96.
CoA	CoA of P62-mediated mitophagy inducer

Smiles:	C1=CC(=CC(=C1)[N+](=O)[O-])C2=CN(N=N2)C3=CC(=CC=C3)I


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