P110

P110 heptapeptide is a peptide inhibitor of the Drp1-Fis1 interaction. P110 heptapeptide has anti-inflammatory, immunomodulatory, mitochondrial protective, and neuroprotective activities. Without blocking the physiological functions of Drp1, P110 heptapeptide reduces pathological functions in many models of neurodegeneration, ischemia, and sepsis. P110 heptapeptide can be used for research on neurological and inflammatory diseases .


Cat. No.: EX-A9661	Purity: >98%

	Chemical structure of P110

For research only, Do not use for Human!

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CAS No.	1411976-18-5
Purity	>98%
Formula	C32H56N10O11
Mol Weight	756.8474
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture, 1 year; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Luis Rios, et al. Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nat Commun. 2023 Jul 19;14(1):4356. [2]. Mukherjee R, et al. Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance. Crit Care Med. 2022 Jun 1;50(6):e504-e515. [3]. Liu W, et al. Brain-targeted heptapeptide-loaded exosomes attenuated ischemia-reperfusion injury by promoting the transfer of healthy mitochondria from astrocytes to neurons. J Nanobiotechnology. 2022 May 23;20(1):242.
CoA	CoA of P110

Smiles:	C([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CC(C)C)=O)CC(C)C)(=O)N1[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)CO)=O)=O)CCCNC(=N)N)=O)CCC1


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