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Product Information:

OTSSP167

OTSSP167 (OTS167) is a highly potent and ATP-competitive MELK inhibitor with IC50 value of 0.41 nM.

Cat. No.: EX-A2119    Purity: >98%
Chemical
Chemical structure of OTSSP167


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1gget quoteIn-stock
5g4650In-stock
10g6920In-stock
25gget quoteInquire


CAS No.1431697-89-0
Purity>98%
FormulaC25H28Cl2N4O2
Mol Weight487.421
Colorlight yellow to yellow
Statesolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Chung S, Suzuki H, Miyamoto T, et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012 Dec 21.

[2]. Li S, et al. Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in gastric cancer. Oncotarget. 2016 Feb 2;7(5):6266-80.

[3]. Ji W, et al. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLoS One. 2016 Apr 15;11(4):e0153518.

[4]. Cho YS, et al. The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor. Biochem Biophys Res Commun. 2014 Apr 25;447(1):7-11.

CoACoA of OTSSP167
Smiles:CN(C)C[C@H]1CC[C@@H](CC1)NC1=C(C=NC2=CC=C(N=C12)C1=CC(Cl)=C(O)C(Cl)=C1)C(C)=O

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