OTS193320

OTS193320 is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM; significantly reduces global H3K9 tri-methylation (H3K9me3) in breast cancer cells in vitro and induces apoptotic cell death, attenuates γ-H2AX levels in combination with doxorubicin compared with the DOX treatment alone, and causes a significant reduction in breast cancer cell viability when compared to the treatment with a single agent; causes growth suppressive effect of SUV39H2-positive A549 lung cancer cells with IC50 of 0.38 uM.


Cat. No.: EX-A7195	Purity: >98%

	Chemical structure of OTS193320

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	600	In-stock
50mg	800	In-stock
100mg	1300	In-stock
200mg	2000	In-stock
500mg	get quote	In-stock
1g	get quote	In-stock

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Synonyms	OTS-193320
CAS No.	2093401-33-1
Purity	>98%
Formula	C28H30ClN5O4
Mol Weight	536.022
Color	Light yellow to yellow
State	solid powder
Solubility	Soluble in DMSO 62.5 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Vougiouklakis, Theodore et al. “Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX.” Oncotarget vol. 9,61 31820-31831. 7 Aug. 2018
CoA	CoA of OTS193320


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