Osimertinib mesylate

Osimertinib mesylate (AZD9291 mesylate) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer[1].


Cat. No.: EX-A1577	Purity: >99%

	Chemical structure of Osimertinib mesylate

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	200	In-stock
250mg	225	In-stock
500mg	250	In-stock
1g	300	In-stock
5g	550	In-stock
10g	800	In-stock

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Synonyms	AZD-9291 mesylate
Synonyms 2	Mereletinib mesylate
CAS No.	1421373-66-1
Purity	>99%
Formula	C29H37N7O5S
Mol Weight	595.713
Color	White to yellow
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Cross DA, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4(9):1046-61. [2]. [2]Hirano T, et al. Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, in EGFR-Mutated Non-Small Cell Lung Cancer. Mol Cancer Ther. 2018 Apr;17(4):740-750.
CoA	CoA of Osimertinib mesylate

Smiles:	CS(O)(=O)=O.COC1=C(NC2=NC(=CC=N2)C2=CN(C)C3=CC=CC=C23)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C


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