Orismilast

Orismilast (LEO-32731) is an orally active and selective PDE4 inhibitor used for the research of inflammatory diseases. Orismilast demonstrates potent inhibition of PDE4B and PDE4D subtype splice variants .


Cat. No.: EX-A10456	Purity: >98%

	Chemical structure of Orismilast

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	618	in_stock
250mg	1222	in_stock
500mg	1976	in_stock
1g	3100	in_stock
2g	4999	in_stock
3g	6095	in_stock

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Synonyms	LEO-32731
CAS No.	1353546-86-7
Purity	>98%
Formula	C19H15Cl2F2NO7S
Mol Weight	510.293
Color	white to off-white
State	powder
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 year; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Nielsen,et al.Preparation of benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors.WO2011160632A1. [2]. Jonathan I Silverberg, et al. Pharmacology of orismilast, a potent and selective PDE4 inhibitor. J Eur Acad Dermatol Venereol. 2023 Apr;37(4):721-729.
CoA	CoA of Orismilast

Smiles:	O=S1(CCC2(OC3=C(C=CC(C(CC4=C(C=[N+](C=C4Cl)[O-])Cl)=O)=C3O2)OC(F)F)CC1)=O


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