ONO-2920632

ONO-2920632 is an orally active and central nervous system (CNS)-penetrant TREK activator, with EC50 values of 0.3 µM and 2.8 μM for TREK-1 and TREK-2, respectively. ONO-2920632 exhibits selectivity for other K2P channels (>91-fold selective versus TASK1, TASK2, TASK3, TRAAK, and TWIK2; 31-fold selective versus TRESK). ONO-2920632 possesses analgesic effects and can be used in research on pain, migraine, and neurological disorders.


Cat. No.: EX-A12793	Purity: >98%

	Chemical structure of ONO-2920632

For research only, Do not use for Human!

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CAS No.	2230296-66-7
Purity	>98%
Formula	C15H10F4N4O2
Mol Weight	354.2591
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yashiro K, et al. Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound. ACS Chem Neurosci. 2025 Mar 5;16(5):960-967.
CoA	CoA of ONO-2920632

Smiles:	O=C(C1=CN2C(C=C1)=NC=N2)NCC3=CC=C(OC(F)(F)F)C=C3F


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