Onapristone

Onapristone is a progesterone receptor antagonist, with Kds of 11.6 nM and 11.90 nM for human endometrium and myometrium progesterone receptor in saturation analysis. Onapristone has antitumor activity .


Cat. No.: EX-A8027	Purity: >98%

	Chemical structure of Onapristone

For research only, Do not use for Human!

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Synonyms	ZK98299
CAS No.	96346-61-1
Purity	>98%
Formula	C29H39NO3
Mol Weight	449.6249

Reference:	[1].Puri CP, et al. Binding characteristics of progesterone and antiprogestin ZK 98.299 in human endometrial and myometrial cytosol. Biochim Biophys Acta. 1989 May 10;1011(2-3):176-82. [2].Huang Y, et al. Inhibiting Nuclear Phospho-Progesterone Receptor Enhances Antitumor Activity of Onapristone in Uterine Cancer. Mol Cancer Ther. 2018 Feb;17(2):464-473.
CoA	CoA of Onapristone

Smiles:	C[C@@]12C[C@@H](C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@]2(CCCO)O)C5=CC=C(C=C5)N(C)C


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