ON1231320

ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 µM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity.


Cat. No.: EX-A2500	Purity: >98%

	Chemical structure of ON1231320

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
100mg	750	In-stock
200mg	1150	In-stock

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CAS No.	1312471-39-8
Purity	>98%
Formula	C22H15F2N5O3S
Mol Weight	467.448
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. M V Ramana Reddy, et al. Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). Bioorg Med Chem. 2016 Feb 15;24(4):521-44. [2]. Shashidhar S. Jatiani, et al. Abstract 643: Targeting cancer with a selective ATP-mimetic inhibitor of polo like kinase-2.
CoA	CoA of ON1231320

Smiles:	CN1C(=O)C(=CC2=CN=C(NC3=CC4=C(NC=C4)C=C3)N=C12)S(=O)(=O)C1=C(F)C=C(F)C=C1


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