Olodaterol

Olodaterol (BI1744) is a selective, long acting β2-adrenoceptor (β2-AR) agonist (EC50=0.1 nM and pKi= 9.14 for human β2-adrenoceptor, respectively). Olodaterol can be used for chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis.


Cat. No.: EX-A1729	Purity: >98%

	Chemical structure of Olodaterol

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	400	In-stock
100mg	550	In-stock
250mg	750	In-stock
500mg	1050	In-stock
1g	1450	In-stock
5g	4850	In-stock

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Synonyms	BI1744
CAS No.	868049-49-4
Purity	>98%
Formula	C21H26N2O5
Mol Weight	386.4415
Color	light yellow to grey
Solubility	Soluble in water
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Xing G, et al. Design, synthesis and biological evaluation of 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one derivatives as potent β2-adrenoceptor agonists. Bioorg Med Chem. 2020;28(1):115178. [2]. Herrmann FE, et al. Olodaterol shows anti-fibrotic efficacy in in vitro and in vivo models of pulmonary fibrosis. Br J Pharmacol. 2017;174(21):3848-3864. [3]. Bouyssou T, et al. Pharmacological characterization of olodaterol, a novel inhaled beta2-adrenoceptor agonist exerting a 24-hour-long duration of action in preclinical models [published correction appears in J Pharmacol Exp Ther. 2013 Jul;346(1):161]. J Pharmacol Exp Ther. 2010;334(1):53-62.
CoA	CoA of Olodaterol

Smiles:	COC1=CC=C(CC(C)(C)NC[C@H](O)C2=CC(O)=CC3=C2OCC(=O)N3)C=C1


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