Oditrasertib

Oditrasertib (SAR443820) is an orally active, BBB-penatrable and selective reversible inhibitor of RIPK1. Oditrasertib can be used in the research of chronic inflammatory central nervous system diseases, such as amyotrophic lateral sclerosis and multiple sclerosis.


Cat. No.: EX-A8863	Purity: >98%

	Chemical structure of Oditrasertib

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	445	in_stock
100mg	609	in_stock
250mg	914	in_stock
500mg	1239	in_stock
1g	1750	in_stock

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Synonyms	DNL788
Synonyms 2	SAR443820
CAS No.	2252271-93-3
Purity	>98%
Formula	C14H15F2N3O2
Mol Weight	295.2846
Color	white to off-white
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Fidalgo JDV, et al. Preparation of substituted oxazepines and related compounds as RIPK1 inhibitors and uses thereof. WO2018213632A1. 2018-11-22. [2]. Hincelin-Mery A, et al. Safety, pharmacokinetics, and target engagement of a brain penetrant RIPK1 inhibitor, SAR443820 (DNL788), in healthy adult participants. Clin Transl Sci. 2024 Jan;17(1):e13690. [3]. Montalban X, et al. Effect of RIPK1 inhibitor, SAR443820, on serum neurofilament light levels in patients with multiple sclerosis: a phase 2 trial design (P6-3.011)[J]. Neurology, 2023, 100(17_supplement_2): 2178.
CoA	CoA of Oditrasertib

Smiles:	N#CC1=CN=CC2=C1OCCN(C2)C(C(C)(C(F)F)C)=O


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