NVP-DFF332

HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity.


Cat. No.: EX-A11306	Purity: >98%

	Chemical structure of NVP-DFF332

For research only, Do not use for Human!

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CAS No.	2734922-78-0
Purity	>98%
Formula	C17H11ClF7N3O
Mol Weight	441.731
Color	White to off-white
State	solid
Solubility	DMSO : 250 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Robin Alec Fairhurst, et al. Compounds and compositions for inhibiting the activity of hif2-alpha and their methods of use. WO2021220170A1.
CoA	CoA of NVP-DFF332

Smiles:	ClC1=NC=CC2=C1C(F)(F)CCC32CN4C=C(C(F)(F)F)C=C(OC(F)F)C4=N3


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