NVP-BSK805 dihydrochloride

NVP-BSK805 dihydrochloride is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.


Cat. No.: EX-A4540	Purity: >98%

	Chemical structure of NVP-BSK805 dihydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	673	in_stock
500mg	1097	in_stock
1g	1731	in_stock
2g	1723	in_stock
5g	3188	in_stock
10g	6283	in_stock

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CAS No.	1942919-79-0
Purity	>98%
Formula	C27H30Cl2F2N6O
Mol Weight	563.47
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55. [2]. Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182.
CoA	CoA of NVP-BSK805 dihydrochloride

Smiles:	FC1=C(CN2CCOCC2)C(F)=CC(C3=C4N=C(C5=CN(C6CCNCC6)N=C5)C=NC4=CC=C3)=C1.Cl.Cl


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