NVP-728

NVP-DPP728 is a potent, reversible and nitrile-dependent dipeptidyl peptidase IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a Ki of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes .


Cat. No.: EX-A10428	Purity: >98%

	Chemical structure of NVP-728

For research only, Do not use for Human!

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Synonyms	NVP-DPP728
CAS No.	247016-69-9
Purity	>98%
Formula	C15H18N6O
Mol Weight	298.343
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hughes TE, et al. NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry. 1999;38(36):11597-11603.
CoA	CoA of NVP-728

Smiles:	N#CC(C=N1)=CC=C1NCCNCC(N2[C@@H](CCC2)C#N)=O


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