NU227326

NU227326 is the PROTAC degrader for Indoleamine 2,3-dioxygenase 1 (IDO1) with DC50 of 4.5 nM. NU227326 degrades IDO1 in cell U87 and GBM43 with DC50 of 7.1 nM and 11.8 nM. NU227326 exhibits good pharmacokinetic properties with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours.


Cat. No.: EX-A16420	Purity: >98%

	Chemical structure of NU227326

For research only, Do not use for Human!

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CAS No.	3048196-52-4
Purity	>98%
Formula	C53H61FN8O7
Mol Weight	941.0992
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Monsen PJ, et al., Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC). J Med Chem. 2025 Feb 27;68(4):4961-4987.
CoA	CoA of NU227326

Smiles:	O=C(NC1=CC=CC(OC2CCN(C(CN3CCC(N4CCN(C5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5)CC4)CC3)=O)CC2)=C1)[C@H](C)[C@@]8([H])CC[C@](C9=C%10C(C=CC(F)=C%10)=NC=C9)([H])CC8


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