NT-0527

NT-0527 is a selective, orally active, and brain-permeable NLRP3 inflammasome inhibitor. NT-0527 can specifically block the formation of the NLRP3 inflammasome, resulting in the reduction in the maturation and release of IL-1β, exhibit inhibition on CYP2C19. NT-0527 displays anti-inflammatory activity in the mouse LPS (HY-D1056) /ATP (HY-B2176)-induced peritonitis model. NT-0527 can be used for the research of neuroinflammatory disorders (Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis) and peripheral inflammatory disorders (type II diabetes, atherosclerosis, gout, etc.) associated with NLRP3 inflammasome .


Cat. No.: EX-A16616	Purity: >98%

	Chemical structure of NT-0527

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	332	In-stock
250mg	650	In-stock
500mg	1180	In-stock
1g	1882	In-stock

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CAS No.	2771019-10-2
Purity	>98%
Formula	C17H14ClFN4O2
Mol Weight	360.77
Color	White to off-white
State	solid
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Harrison D, et al. Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an in vivo tool compound for neuroinflammatory disorders. RSC Med Chem. 2025 Sep 4.
CoA	CoA of NT-0527

Smiles:	O=C1C2=CC=C(Cl)C=C2C3(CN1CC(=O)NC4=NC=C(F)C=N4)CC3


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