NST-628

NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation. NST-628 also binds RAF and prevents the formation of BRAF-CRAF and BRAF-ARAF heterodimers, effectively inhibiting the RAS-MAPK pathway.


Cat. No.: EX-A8853	Purity: >98%

	Chemical structure of NST-628

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	551	in_stock
250mg	856	in_stock
500mg	1326	in_stock
1g	1853	in_stock

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CAS No.	3002056-30-3
Purity	>98%
Formula	C22H18F2N4O5S
Mol Weight	488.464
Color	White to off-white
State	solid
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ryan M B, et al. Abstract ND10: NST-628 is a novel, potent, fully brain-penetrant MAPK pathway molecular glue that inhibits RAS-and RAF-driven cancers[J]. Cancer Research, 2024, 84(7_Supplement): ND10-ND10.
CoA	CoA of NST-628

Smiles:	FC1=C(OC2=CC=C(C(C)=C(CC3=C(F)C(NS(NC)(=O)=O)=NC=C3)C(O4)=O)C4=C2)N=CC=C1


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