NSC-636819

NSC636819 is a competitive and selective inhibitor of KDM4A/KDM4B. KDM4A/KDM4B are potential progression factors for prostate cancer. NSC636819 has the potential for the research of cancer diseases, especially prostate cancer.


Cat. No.: EX-A11212	Purity: >98%

	Chemical structure of NSC-636819

For research only, Do not use for Human!

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CAS No.	1618672-71-1
Purity	>98%
Formula	C22H12Cl4N2O4
Mol Weight	510.154
Color	Yellow to orange
State	solid
Solubility	DMSO : 5.1015 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Chu CH, et al. KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J Med Chem. 2014;57(14):5975-5985. [2]. Wang J, et al. Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. Cell Death Differ. 2016 Nov 1;23(11):1886-1896.
CoA	CoA of NSC-636819

Smiles:	ClC1=C(Cl)C=CC(/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC(Cl)=C(Cl)C=C3)=C2)=C1


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