NS8593 hydrochloride

NS8593 HCl is a selective KCa2 (SK) channel negative modulator. NS8593 inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca2+). It exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels.


Cat. No.: EX-A5293	Purity: >98%

	Chemical structure of NS8593 hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	550	In-stock
100mg	895	In-stock
200mg	1450	In-stock

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CAS No.	875755-24-1
Purity	>98%
Formula	C17H18ClN3
Mol Weight	299.798
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 83.33 mg/mL H2O 1 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sørensen US, et al. Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels. J Med Chem. 2008 Dec 11;51(23):7625-34. [2]. Strøbaek D, et al. Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons. Mol Pharmacol. 2006 Nov;70(5):1771-82.
CoA	CoA of NS8593 hydrochloride

Smiles:	[H]Cl.C1(N[C@@H]2CCCC3=C2C=CC=C3)=NC4=CC=CC=C4N1


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