NS383

NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits.


Cat. No.: EX-A11211	Purity: >98%

	Chemical structure of NS383

For research only, Do not use for Human!

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Synonyms	NS 383
CAS No.	309711-59-9
Purity	>98%
Formula	C19H19N3O2
Mol Weight	321.3731
Color	Light yellow to yellow
State	solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Munro G, et al. NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats. CNS Neurosci Ther. 2016;22(2):135-145.
CoA	CoA of NS383

Smiles:	O=C1NC2=C(CN(CC3)CC)C3=C(C4=CC=CC=C4)C=C2/C1=N/O


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